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KMID : 0353320150390020155
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Oral Biology Research
2015 Volume.39 No. 2 p.155 ~ p.158
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Evaluation of gargling Cololo solution for bacterial growth inhibition
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Park A-Young
Kang A-Young
Park Chan-Young
Hong Seung-Hye
Lee Dae-Yoon
Lee Yun-Jae
Jung Suk-Yul
Shin Ho-Joon
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Abstract
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Purpose: The aims of this study were to analyze whether or not Cololo SP solution developed in Japan could be an alternative or superior to Hexamedine solution.
Materials and Methods: Analysis was done by evaluating the bactericidal effects of mouthwash. Several methodologies tested, e.g., mixing bacteria directly into the mouthwash and long-term treatment of bacteria with solution.
Results: Bacterial suspension treated twice with 80-fold diluted Cololo SP solution (1 hour of incubation at room temperature [RT] and 4 hours of incubation at RT) was more effective than single-directed inoculation of bacteria mixed with Cololo SP solution.
Conclusion: The recommended dosage for Hexamedine solution application is two times for 1 min/d, and application should not be continued for more than 2 weeks. Thus, a new therapy needs to be developed to facilitate its continuous application as a mouthwash. Hexamedine solution is generally harmful if used for even 10 days. Therefore, our data suggest that Cololo SP solution would be a better alternative to Hexamedine solution.
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KEYWORD
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Bacterial inhibition, Cololo SP solution, Hexamedine
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